Naproxen USP(NSAID) TradeName :Napro-A.Naprox,Sonap,Naprosyn,Servinaprox

TradeName :Napro-A.Naprox,Sonap,Naprosyn,Servinaprox(BD)

Naproxen USP

Naproxen USP is a nonsteroidal anti-inflammatory drug (NSAID) with analgesic, anti-inflammatory and antipyretic properties. Naproxen is a propionic acid derivative related to the arylacetic acid class of drugs. The chemical name of naproxen is (+)-6-methoxyalpha- methyl-2-naphthaleneacetic acid. Naproxen has been shown to have striking anti-inflammatory properties when tested in human clinical studies and classical animal test systems. In addition, it has marked analgesic and antipyretic actions. It inhibits synthesis of prostaglandins.

Naproxen Presentation:

Naproxen USP250 Tablets: Each tablet contains Naproxen USP 250 mg.
Naproxen USP500 Tablets: Each tablet contains Naproxen USP 500 mg.
Naproxen USP50 ml suspension: After reconstitution according to direction, each 5 ml suspension contains Naproxen Sodium USP powder equivalent to Naproxen 125 mg.

General Onset of pain relief can begin within 1 hour in patients taking naproxen. A lower dose should be considered in patients with renal or hepatic impairment or in elderly patients. Naproxen USPis not recommended in patients with baseline creatinine clearance less than 10 ml/minute because accumulation of naproxen metabolites has been seen in such patients. Naproxen USPmay be given orally either in fasting state or with meals and/or antacids. Dose in adults Chronic conditions: Osteoarthritis / Rheumatoid arthritis / Ankylosing spondylitis / chronic pain states in which there is an inflammatory component: The recommended dose of naproxen is Naproxen USP250 mg or 500 mg taken twice daily (morning and evening), or a single daily dose of 500-1000 mg given in the morning or evening, or 500 mg taken twice daily, or a single daily dose of 1000 mg given in the evening. During long-term administration the dose of naproxen may be adjusted up or down depending on the clinical response of the patient. A lower daily dose may suffice for long-term administration. In patients who tolerate lower doses well, the dose may be increased to 1500 mg per day when a higher level of anti-inflammatory/analgesic activity is required. When treating patients with naproxen 1500 mg/day, the physician should observe sufficient increased clinical benefit to offset the potential increased risk (see Precautions). The morning and evening doses do not have to be equal in size and administration of the drug more frequently than twice daily does not generally make a difference in response. Acute conditions: Analgesia / Dysmenorrhoea / Acute musculoskeletal conditions/Acute pain states in which there is an inflammatory component: The recommended starting dose is Naproxen USP500 mg followed by Naproxen USP250 mg every 6-8 hours as required.

Naproxen Side Effects:-

Gastrointestinal: abdominal pain, constipation, diarrhea, dyspepsia, heartburn, nausea, stomatitis. Central nervous system: dizziness, drowsiness, headache, lightheadedness, vertigo. Dermatologic: ecchymoses, itching (pruritus), purpura, skin eruptions, sweating.Special senses: hearing disturbances, tinnitus, visual disturbances. Card

Use in Pregnancy and Lactation Naproxen :-

Pregnancy: As with other drugs of this type, naproxen produces delay in parturition in animals and also affects the human fetal cardiovascular system (closure of ductus arteriosus). Therefore, naproxen should not be used during pregnancy unless clearly needed.

Naproxen Drug Interaction  :-

Concomitant administration of antacid or cholestyramine can delay the absorption of naproxen , but does not affect its extent. Concomitant administration of food can delay the absorption of naproxen, but does not affect its extent. Naproxen is highly bound to plasma

Naproxen Over Dosage :-

If a patient ingest a large amount of naproxen, accidentally or purposefully, the stomach should be emptied and the usual supportive measures employed. Animal studies indicate that the prompt administration of 50-100 g of activated charcoal as an aqueous slurry over 15 minutes within 2 hours of the overdose would tend to reduce markedly the absorption of the drug. Hemodialysis does not decrease the plasma concentration of naproxen because of the high degree of its protein binding.

Storage

Naproxen USPStore at below 35°C.
The reconstituted suspension should be store in cool and dry place and used within 14 days after preparation.
Keep out of reach of children.